Skin Protectant Lotion | DIFINSA53


Make a Difference in Your Patients’ Compliance to Radiation Therapy


Skin Reactions Are Everyone’s Concern


ErythemaSkin reactions like erythema and dry desquamation occur almost universally in patients undergoing radiation therapy. You see this in your own practice. So does the clinical research, with at least one study estimating some degree of skin damage in 85% to 95% of radiation therapy patients1.

Uncomfortable skin reactions erode your patients’ sense of well-being during an already-stressful time, and can worsen to the point of disrupting the treatment schedule.



Defend the Dermis


DIFINSA53Skin Protectant Lotion lets you make a positive difference in your patient’s quality of life and their compliance to therapy by helping them feel soothed and protected between radiation treatments.

DIFINSA53™ lotion is a non-prescription, over-the-counter medication for use on skin exposed to radiation. It is specifically formulated to help prevent, temporarily protect, and relieve chafed, chapped or cracked skin.



Safe and Soothing


DIFINSA53™ lotion contains a proprietary, patent-pending formulation of ingredients. It is the result of ten years of research and development by a multidisciplinary team of scientists and doctors at the University of Colorado Anschutz Medical Center.

DimethiconeThe active skin protectant ingredient in DIFINSA53™ lotion is a silicone fluid called dimethicone 1%. Widely used in cosmetics, dimethicone is “generally regarded as safe” by the U.S. Food and Drug Administration and is clinically-proven to be non-irritating to the skin2-4. Four natural botanical ingredients (Silibinin [silybum], hyaluronic acid, aloe vera and niacinamide) in Difinsa53™ lotion will also soothe, not sting, your patients’ skin.

DIFINSA53™ lotion is hypoallergenic, non-greasy, non-sticky and absorbs quickly into the skin. Your patients will also appreciate its light, pleasant aroma.



Use Between Treatments and Beyond


Use After Treatment

DIFINSA53™ lotion comes in a pump-action, metered-dose dispenser, so your patients can easily apply just the right amount to cover their affected skin without wasting excess lotion. Patients can safely start using DIFINSA53™ lotion as soon as they wish at least twice a day, and then daily as needed between their treatments.

Pump ActionPatients can also continue using DIFINSA53™ lotion even after their series of treatments is over. Once they’ve returned to an active lifestyle, they can apply it before going outdoors, to help prevent, and protect from, the drying effects of wind and cold weather.

Do not apply DIFINSA53™ lotion to open wounds. Instead, please discontinue the use of DIFINSA53™ lotion and use your preferred hydrogel wound dressing.

For more information on usage, please view the Difinsa53™ Patient Directions for Use.



Steeped in Science, Developed by Doctors


Steeped in Science

DIFINSA53™ lotion was developed by scientists, radiation oncologists and dermatologists at the University of Colorado Anschutz Medical Center. Several of these experts founded ProTechSure Scientific, Inc. to commercialize this and other discoveries. All of us at ProTechSure Scientific, Inc. care deeply about improving the quality of life for radiation therapy patients and are committed to continuing research into new skin care medications.



Clinical Trials Are Ongoing


Clinical TrialOur clinical experience and the literature to date support our belief that topical dimethicone may have superior efficacy in relieving minor irritation in irradiated skin5. Clinical trials are continuing and we would welcome your participation. If you are interested in conducting a study in your own practice, please contact our medical director or call 720-500-2266.



Start Making the DIFINSA53™ Difference Today!


Sample DisplayWe provide you with complete assistance to make DIFINSA53™ lotion available to your patients. Contact us today to obtain your supply of DIFINSA53™ samples, a Sample Starter Kit and Patient Brochures. Or, call us at 720-500-2266.

Your patients can easily reorder DIFINSA53™ lotion on this website. They can also read about its ingredients, how to use it and how to take care of their skin during radiation therapy. They can also find answers to frequently-asked questions about DIFINSA53™ lotion.





1 McQuestion M. Evidence-based skin care management in radiation therapy. Sem Oncol Nursing 2006 Aug; 22(3): 163-73.

2 Becker LC et al. Safety assessment of dimethicone crosspolymers as used in cosmetics. Int J Toxicol 2014 May/June; 33 (2): Suppl 65S-115S.

3 Nair B. Final report on the safety assessment of stearoxy dimethicone. Int J Toxicol 2003; 22 Suppl 2: 11-35.

4 Raposo S et al. Safety assessment and biological effects of a new cold processed silemulsion for dermatogolical purpose. Biomed Res Int. 2013; 2013: 181634. Published online 2013 Nov 5:

5 Becker-Schiebe M et al. Topical use of a silymarin-based preparation to prevent radiodermatitis. Strahlenther Onkol 2011; 187: 485-91.



The Difference Is DIFINSA53™

  • Prevents, protects, and relieves chafed, chapped or cracked skin
  • Prevents, and protects from, the drying effects of wind and cold weather
  • Relieves skin irritation
  • Soothes and hydrates the skin
  • Non-greasy, fast-absorbing
  • Light, pleasant aroma
  • Hypoallergenic
  • Dermatologist-approved
  • Developed by university doctors



"At ProTechSure Scientific, we are dedicated to improving the quality of life for patients. To accomplish this, we utilize rigorous medical evidence and adhere to the highest standards. DIFINSA53™ has been specifically formulated by an interdisciplinary team of doctors of oncology, dermatology and pharmacology at the University of Colorado Anschutz Medical Campus."

Michael Glodé, M.D.

Dr. Glodé is a Medical Oncologist, University Professor, Cancer Survivor and a Founding Member of ProTechSure Scientific, Inc.

"ProTechSure is about bringing skin science to the people who can benefit from it. This is our motivation. As a physician, you are limited to helping the people you come in contact with, but applying a scientific discovery allows us the opportunity to help a greater number of people."

Theresa Pacheco, M.D.

Dr. Pacheco is a Dermatologist, Associate Professor and Founding Member of ProTechSure Scientific, Inc.